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Tamixofen also known as Nolvadex is used to reduce the occurrence of breast cancer in women who have a high possibility of acquiring the disease. Nolvadex is in tablet form. It is a nonsteroidal, anitestrogen, oral medication. It is available in 10mg tablets and 20 mg tablets. Each 10 mg tablet has 15.25 mg of Tamixofen citrate and is equal to 10 mg of Tamixofen. Each 20mg tablet contains 30.4mg of Tamixofen citrate and is equal to 20 mg of Tamixofen. The usual loading dose of women suffering from breast cancer is 20-40mg on a daily basis. Dosages which are more than 20 mg a day should be given Nolvadex in two separate doses, one in the evening and one in the morning.

This was proven in a planned study which lasted for 5 years and with a median follow-up of 4.2 years. 25% of the subjects were given Nolvadex for 5 years. However, long-term effects of the drug are still unknown. This study was a success since it had no impact on the on the whole breast cancer related mortality rate. This is indicated for “high risk” women. High risk meaning; women who are in any case 35 years old which is predicted to have breast cancer in 5 years ≥ 1.67% as calculated by the Gail model.

Nolvadex can cause a lot of side effects. This will be listed below:

- Tingly or warmth feeling under the skin - Purpura - Edema in the hands or feet - Cough - Soar throat - Impotency or difficulty in having an orgasm - Thinning of the hair - Nausea - Weight loss

Adverse effects include:

- Pain or edema on both legs - Unusual vaginal bleeding or discharge - Symptoms of flu - New breast lumps - Angina pectoris - Bradypnea - Confusion or headache - Impaired sensory and cognitive functions - Coughing of blood

If ever any of these effects will manifest, go to your doctor immediately and seek advice on what to do.